課程名稱 |
藥品動態學 Pharmacokinetics |
開課學期 |
105-1 |
授課對象 |
醫學院 藥學研究所 |
授課教師 |
林君榮 |
課號 |
PHARM7005 |
課程識別碼 |
423 M0400 |
班次 |
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學分 |
2 |
全/半年 |
半年 |
必/選修 |
必修 |
上課時間 |
星期三9,10(16:30~18:20) |
上課地點 |
水森415 |
備註 |
與余秀瑛、胡幼圃、林淑文合開 總人數上限:20人 |
Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/1051PHARM7005_ |
課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
課程大綱
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課程概述 |
Advance Pharmacokinetics is a continued course for Biopharmaceutics and Pharmacokinetics. The major purpose of this course is to teach students how to solve pharmacokinetic or pharmacodynamic problems using mathematical approaches. Some of the information and concepts from mathematics and elementary pharmacokinetics will be reviewed or developed as needed, but the balance of prerequisite material will be the student’s responsibility. Readings and homework will be assigned, or may be suggested to improve the learning efficiency of students. |
課程目標 |
Several topics will be introduced and elaborated in this course: Compartment Models; Pharmacokinetic / Pharmacodynamic (PK/PD) models; Physiological models; Nonlinear Pharmacokinetics; Absorption kinetics; Noncompartmental analysis;
Population pharmacokinetics. |
課程要求 |
It is important to develop an independent ability to construct pharmacokinetic (PK) and/or pharmacodynamic (PD) models corresponding to situations encountered in research and clinical study.
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預期每週課後學習時數 |
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Office Hours |
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指定閱讀 |
handout and the assigned references |
參考書目 |
Gibaldi and Perrier, Pharmacokinetics, 1982
Wagner, Fundamental of clinical pharmacokinetics, 1975
Rowland and Tozer, Clinical pharmacokinetics, 1995
Guterman and Nitecki, Differential equations, 1992
In addition to the recommended texts above, readings from other books, review articles or the primary scientific literature may be assigned or recommended by each instructor. Some of the faculty may also provide handout notes as a guide or supplement to their lectures.
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評量方式 (僅供參考) |
No. |
項目 |
百分比 |
說明 |
1. |
期中考 |
50% |
(1) 期中考含討論及筆試
(2) 各老師所占分數依上課時分配
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2. |
期末考 |
50% |
各老師所占分數依上課時分配
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週次 |
日期 |
單元主題 |
第1週 |
9/14 |
Introduction and Clearance Concepts |
第2週 |
9/21 |
Interspecies scaling (Allometry and PBPK) |
第3週 |
9/28 |
Compartment Models and Laplace Transform |
第4週 |
10/05 |
PK/PD Modeling |
第5週 |
10/12 |
Brief introduction of R |
第6週 |
10/19 |
Application of R in Pharmacometrics |
第7週 |
10/26 |
Population Pharmacokinetics |
第8週 |
11/02 |
PK/PD of Antibiotics |
第9週 |
11/09 |
Application of LC/MS/MS in Pharmacokinetic Study and Drug Development |
第10週 |
11/16 |
期中考 |
第11週 |
11/23 |
Tissue Distribution and Protein Binding |
第12週 |
11/30 |
Effect of a Drug on Serum Bilirubin Level and Risk |
第13週 |
12/07 |
Elucidate Contradictory Clinical Reports on Metabolic Rate of a Drug |
第14週 |
12/14 |
Nonlinear Pharmacokinetics- I&II |
第15週 |
12/21 |
Noncompartmental Analysis |
第16週 |
12/28 |
Absorption kinetics- I |
第17週 |
1/04 |
Absorption kinetics- II&III |
第18週 |
1/11 |
期末考 |